Unbalancing p53/Mdm2/IGF-1R axis by Mdm2 activation restrains the IGF-1-dependent invasive phenotype of skin melanoma.

Oncogene · 2017 · PMC5474566 · PMID 28092675

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did not reach statistical significanceno p-value reported

showed a trendno p-value reported

The mtp53 cell line BE showed a trend toward Nutlin-3-dependent IGF-1R degradation in the presence of IGF-1 but only displayed a 20% decrease at 1 μ M Nutlin-3 concentration, which did not reach statistical significance.

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