The Significance of the Sulfatase Pathway for Local Estrogen Formation in Endometrial Cancer.

Front Pharmacol · 2017 · PMC5481366 · PMID 28690541

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a clear trendno p-value reported

Additionally, IHC staining for SULT1E1 was negative (>25% cases) or weak with a clear trend for decreased levels in EC (Supplementary Table 4 ).

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did not reach statistical significanceno p-value reported

The importance of the sulfatase pathway is also supported by the previously reported 5-fold lower expression of SULT1E1 as compared to STS and decreased mRNA levels of SULT1E1 in 27 out of 38 EC samples from the same cohort, where this difference did not reach statistical significance (Hevir et al., 2011b ) and also by significantly increased ratio between STS and SULT1E1 in EC.

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