Prostate and endometrial cancers showed a negative trend.
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Other cancers in lung cancer families are overwhelmingly smoking-related cancers.
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Among the 14 cancers without established relation to smoking (according to IARC), a significant trend test was observed for anal, breast and squamous cell skin cancers.
Compared to families with no lung cancer in FDRs, the RRs for all histological types were also highly significant when at least one FDR was diagnosed.