Long-term survival benefit of upfront chemotherapy in patients with newly diagnosed borderline resectable pancreatic cancer.

Adjusting for other baseline clinicopathologic factors, BL‐PDACs with both arterial and venous involvement had marginally significant lower odds of resectability than those involving vein only (OR, 0.37; 95% CI, 0.13–1.06; P = 0.06).

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As shown by the univariate and multivariate Cox regression analysis (Table S4 ; Table 5 ), upfront chemotherapy followed by chemoradiation may be associated with a better RFS when compared to chemoradiation alone, (HR, 0.44; 95% CI, 0.12–1.53) although the differences did not reach statistical significance likely due to the small sample sizes.

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Even BL‐PDAC with isolated arterial involvement had a strong trend toward better PFS than those with isolated venous involvement (HR, 0.31; 95% CI, 0.09–1.09).

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