DNA methylation of candidate genes in peripheral blood from patients with type 2 diabetes or the metabolic syndrome.

Exclusion of these outliers resulted in a loss of statistical significance, although a positive trend remained between PEG3 methylation and HDL cholesterol (p = 0.05).

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A similar trend toward significance was observed for this gene between the controls and all metabolic patients (i.e. the MetS and T2D patients) (p = 0.07).

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Arner et al did not observe significant differentially methylated loci between those individuals identified with and without insulin resistance, although some loci were nominally significant[ 46 ].

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Results Differential DNA methylation between patient groups Differences in DNA methylation levels between the three subgroups were small and did not reach statistical significance for any of the genes, although a trend towards significance was observed for the PEG3 gene (p = 0.07) ( Fig 1 and Table 2 ).

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Results No significant differences in gene-specific methylation between patients and controls were observed, although a trend towards significance was observed for PEG3 .

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