As shown in Figure 5 , ATF5-KD showed a trend toward increased cleaved caspase 3 levels (which did not reach the threshold of statistical significance) in Mvt1 cells (Figures 5 A,B) and in Met1 cells (Figures 5 C,D).
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Activating Transcription Factor-5 Knockdown Reduces Aggressiveness of Mammary Tumor Cells and Attenuates Mammary Tumor Growth.
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However, apoptotic regulation may not be the principal mechanism underlying this effect, since the elevation in cleaved caspase 3 levels did not reach statistical significance.