Genetic and Functional Associations with Decreased Anti-inflammatory Tumor Necrosis Factor Alpha Induced Protein 3 in Macrophages from Subjects with Axial Spondyloarthritis.

The results from the linear regression model, adjusted for age and sex covariates, yielded several nominally significant variants in the PTPN2 region including the top finding of rs78943928 ( p = 1.69E−04) which resides approximately 29 and 22 kbp 3′ of PTPN2 isoform 1 and isoform 2, respectively.

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Variants rs5029937, rs5029939, and F127C have previously been reported to associate with RA and SLE and showed a trend toward lower levels in this study ( 45 , 46 ).

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We observed highly significant positive correlations between phosphorylated IkBα (Figure 2 A), MAP kinase (e.g., ERK, JNK) and TNFAIP3 levels.

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