Hypoxia ameliorates intestinal inflammation through NLRP3/mTOR downregulation and autophagy activation.

Although histology samples did not show any differences in the inflammatory status of patients with IBD prior to or after hypoxia, immunostaining for p62 of distal colon sections showed a trend towards reduced protein levels of p62 1 week after hypoxia in HV and patients with CD, indicating a hypoxia-mediated increase in autophagy flux (Fig. 1g , arrowheads ).

also in 53,322 other papers

Although not significant, our results also show a clear trend towards an increase in the mRNA levels of Lc3 under hypoxia (Fig. 3g ).

also in 19,460 other papers