Absence of Tissue Inhibitor of Metalloproteinase-4 (TIMP4) ameliorates high fat diet-induced obesity in mice due to defective lipid absorption.

Decreased lipid digestion cannot be completely ruled out in HFD-fed Timp4 −/− mice as these mice showed a strong trend in decreased pancreatic lipase activity compared to HFD-fed WT mice.

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The HFD-induced rise in expression of inflammatory markers did not reach statistical significance in Timp4 −/− mice, while macrophage infiltration was markedly lower in these mice compared to WT-HFD mice (Fig. 3F ).

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