Connectivity in gene coexpression networks negatively correlates with rates of molecular evolution in flowering plants.

When combining our results across all seven taxa, we found that the overall pattern–i.e., more highly interconnected hub genes exhibited stronger evolutionary constraint–was highly significant (Fisher’s combined probability test, P < 1E-08 for both dN and ω [using CombinePValue; https://CRAN.R-project.org/package=CombinePValue ]; S2 Appendix ).

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were nominally significant based on our randomization tests, but not significant after controlling for multiple comparisons; Fig 2A ).

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While the remaining six comparisons resulted in negative τ values, none of them individually approached significance.

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