Methylomic profiling of cortex samples from completed suicide cases implicates a role for PSORS1C3 in major depression and suicide.

Pathways were filtered to those containing between 10 and 2000 genes, and a list of nominally significant pathways ( P <0.05) was identified as described previously. 41 Replication analyses in an independent prefrontal cortex sample Post-mortem prefrontal cortical tissue samples were obtained from the National Institute of Child Health and Human Development Brain and Tissue Bank for Developmental Disorders at the University of Maryland as described in detail elsewhere. 18 These brain samples include suicide cases whose psychiatric diagnoses are unclear.

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Although overall patterns of DNA methylation did not reach statistical significance (Brown’s P -value= 0.13), two CpG sites within the DMR were significantly differentially methylated between cases and controls (cg26818629 ( P =0.03); cg26668675 ( P =0.04), see Figure 2c ; Supplementary Table S5 ).

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