A systematic review and meta-analysis of preclinical trials testing anti-toxin therapies for B. anthracis infection: A need for more robust study designs and results.

Although these relationships between time and the effects of anti-toxin agents on the log relative risk of death [slope in log(RR) (95% CI)] did not reach significance for either AIG [-0.023 (-0.060, 0.015), p = 0.24] or ETI-204 [-0.042 (-0.104, 0.021), p = 0.19] alone, the trend for the two agents when combined approached significance [-0.028 (-0.060, 0.005), p = 0.09].

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Furthermore, when examined within species and across anti-toxin agents, treatment had consistent beneficial effects in rabbits and cynomolgus monkey models in patterns that were significant or had a significant trend.

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