Autophagy couteracts weight gain, lipotoxicity and pancreatic β-cell death upon hypercaloric pro-diabetic regimens.

25 , 26 Moreover, plasma values of certain pro-inflammatory cytokines and chemokines, including IFN γ or IL-6, were slightly augmented in atg4b −/− mice when subjected to high-calorie regimens, in accord with previous studies linking higher pro-inflammatory responses the absence of ATG4B, 20 although these differences failed to reach statistical significance ( Supplementary Figure 1C ).

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Surprisingly, atg4b −/− mice tended to reduce their food and water intake under high-fat diet or sucrose treatment, although this trend did not reach statistical significance ( Supplementary Figure 3 ).

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