Isothiocyanate-enriched moringa seed extract alleviates ulcerative colitis symptoms in mice.

MSE showed a positive trend in reversing colon shortening (6.9 ± 0.1 cm for acute UC, not significant at p<0.05; and 7.3 ± 0.3 cm for chronic UC). 5-ASA did not recover colon shortening in either model (6.4 ± 0.3 cm for acute UC; 6.6 ± 0.2 cm for chronic UC) ( Fig 2B ).

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MSE showed a trend in reducing histopathological scores in acute UC, which was not significant at p<0.05 ( Fig 3C ).

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DSS normally suppresses claudin-1 gene expression; however, MSE increased claudin-1 expression in both UC models and the effect was highly significant in the acute model (558%) ( Fig 5E ).

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In chronic UC, MSE showed a strong trend towards reducing clinical symptoms compared to disease control starting from d 2 (-73.3%).

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