Enhanced ventral hippocampal synaptic transmission and impaired synaptic plasticity in a rodent model of alcohol addiction vulnerability.

Second, we observed a strong trend toward smaller LTP magnitudes in vHC slices from aSI rats relative to aGH rats.

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Short-term plasticity experiments showed a trend toward lower paired pulse ratios in vHC slices (Fig. 6B ; aGH dHC: n = 20 slices, 14 rats; aGH vHC: n = 22 slices, 14 rats), with statistically significant differences at the 75 ms (aGH dHC: 1.53 ± 0.037; aGH vHC: 1.41 ± 0.038; t(40) = 2.30, p = 0.027, Student’s t-test) and 300 ms (aGH dHC: 1.20 ± 0.023; aGH vHC: 1.12 ± 0.024; t(40) = 2.37, p = 0.023, Student’s t-test) interstimulus intervals.

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Within both aGH and aSI groups, our evaluation of short-term plasticity revealed an overall trend toward lower paired pulse ratios in vHC slices compared to dHC slices, with statistically significant differences at several interstimulus intervals.

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