Clearance of beta-amyloid is facilitated by apolipoprotein E and circulating high-density lipoproteins in bioengineered human vessels.

With respect to tissue accumulation, Aβ42 levels were significantly lower and Aβ40 levels showed a trend toward lower levels in tripartite compared to bipartite vessels ( Figure 7h,i ).

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After 24 hr, we observed a strong trend toward decreased tissue levels of accumulated Aβ40 and significantly lower accumulated Aβ42 in the presence of HDL ( Figure 4g–h ).

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