Male apoE*3-Leiden.CETP mice on high-fat high-cholesterol diet exhibit a biphasic dyslipidemic response, mimicking the changes in plasma lipids observed through life in men.

Endogenous glucose production Tracer kinetics showed a trend for decreasing AUC and mean residence time over time, whereas for bioavailability, apparent volume of distribution, metabolic clearance rate, and glucose pool size the parameters decreased from 3 to 15 weeks HFCD followed by an increase at the 27‐week time point (Fig.

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In contrast, fecal bile acid excretion does not show an obvious trend over time (Fig. 11 ).

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Inspection of the HDL‐c data does not convey a clear trend through time (Fig. 3 C).

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