Effect of diacerein on renal function and inflammatory cytokines in participants with type 2 diabetes mellitus and chronic kidney disease: A randomized controlled trial.

PLoS One · 2017 · PMC5648185 · PMID 29049415

Europe PMC DOI

hedged sentences

0.0500

closest p · 1.0× alpha

0.1500

boldest claim

The sentences

reached borderline significanceP = 0.05actually significant

As shown in Fig 3 , the comparison between the groups regarding TNF-α levels reached borderline significance ( P = 0.05).

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borderline significanceP = 0.05actually significant

While the diacerein group had reduced TNF-α levels at the 75th percentile with a borderline significance (P = 0.05), there were no changes in the IL levels at the 75 th percentile.

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showed a trendP < 0.15not close (p > 0.1)

At baseline, diacerein-treated participants showed a trend (P < 0.15) toward lower systolic and diastolic blood pressures compared to placebo participants, which is consistent with more frequent use of ACE inhibitors.

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