Efficacy and Safety of a Chewable Methylphenidate Extended-Release Tablet in Children with Attention-Deficit/Hyperactivity Disorder.

J Child Adolesc Psychopharmacol · 2017 · PMC5651935 · PMID 28557548

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hedged sentences

0.0540

closest p · 1.1× alpha

0.1330

boldest claim

The sentences

approached significancep = 0.054so close (0.05 < p ≤ 0.1)

For the average overall postdose time points, the PERMP total number of problems attempted was significantly greater for subjects treated with MPH ERCT compared with subjects treated with placebo (LS mean difference [95% confidence interval], 24.5 [4.4, 44.7]; p = 0.017); the treatment difference for total number correct approached significance (20.5 [−0.3, 41.4]; p = 0.054).

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did not reach statistical significancep = 0.133not close (p > 0.1)

The 10-hour comparison did not reach statistical significance ( p = 0.133), and all subsequent comparisons in the fixed sequence (12-, 13-, and 0.75-hour time points) were considered nonsignificant.

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likely to be significantno p-value reported

The order for the fixed-sequence testing procedure was selected a priori to test time points starting with the most likely to be significant and moving to the least (based on the time course of other MPH ER formulations) (Pelham et al. 2001 ; McGough et al. 2006 ; Kimko et al. 2012 ; Wigal et al. 2014 ).

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