The Indirubin Derivative 6-Bromoindirubin-3'-Oxime Activates Proteostatic Modules, Reprograms Cellular Bioenergetic Pathways, and Exerts Antiaging Effects.

S5B 2 ); notably, however, although 6BIO-Pip showed a trend to increase mean and median life span of flies up to 150 μ M , it did not increase maximum longevity and differences were significant only at 50 μ M of added 6BIO-Pip ( Supplementary Fig.

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S7A ) activity; yet, at the doses (or the duration of the treatment) used herein, this effect did not reach statistical significance.

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