Hepatic GALE Regulates Whole-Body Glucose Homeostasis by Modulating <i>Tff3</i> Expression.

Diabetes · 2017 · PMC5652600 · PMID 28877911

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showed a trendno p-value reported

Basal and glucose-stimulated insulin levels in mice infected with Tff3 AAV showed a trend to be lower, independent of the Gale overexpression status of the mice ( Fig. 5 E ).

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a strong trendno p-value reported

The ratio of hepatic UDP-Glc to UDP-Gal levels was increased in Gale TG livers, and the ratio of UDP-GlcNAc to UDP-GalNAc levels had a strong trend of being suppressed by Gale overexpression ( Fig. 1 G ), suggesting that GALE is enzymatically active in our mouse model.

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