miR-204 is associated with an endocrine phenotype in human pancreatic islets but does not regulate the insulin mRNA through MAFA.

miR-204 was also clearly expressed in the human β cell line EndoC-βH1, with a median of 4612 copies/ng of total RNA (range 1642–17576) measured in 9 RNA preparations collected at different time points in culture. Correlation in human islets of miR-204 , MAFA , INS , TXNIP , and TRPM3 mRNA levels measured by ddPCR In purified human islets INS mRNA levels showed a trend towards a partial correlation with those of the MAFA transcripts, although it did not reach statistical significance, (Spearman r = 0.75, p = 0.063) (Fig. 4a ), and no correlation with those of miR-204 (Spearman r = 0.357, p = 0.444) (Fig. 4b ).

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Levels of both miR-204 and miR-375 showed a trend towards a positive correlation with the degree of islet purity although statistically not significant ( miR-204 Spearman R = 0.62, p = 0.14; miR-375 Spearman R = 0.68, p = 0.11).

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