Polygenic risk scores (PRS) for reproductive aging phenotypes and breast cancer risk The correlations between the PRS for each reproductive aging phenotype and the phenotype itself were highly significant as expected (p≤0.0002); yet the strength of the correlations was weak (correlation coefficient 0.16–0.21) ( Table 6 ).
In addition, the 4 th and 5 th highest quintiles of PRS for AM were associated with increased breast cancer risk, with a borderline significant trend; yet no association was found with PRS for ANM.
We replicated a number of variants in EA women, including rs7759938 in LIN28B for AM and rs16991615 in MCM8 for ANM; whereas in the AA group, only one SNP (rs2947411 in TMEM18 ) for AM was directionally consistent and nominally significant.