The incidence of microcracks varied considerably, but the difference between hip fracture and non-fracture controls in terms of microcrack density failed to reach statistical significance.
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The effect of long-term bisphosphonate therapy on trabecular bone strength and microcrack density.
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The sentences
This preliminary study suggests that the clinical impact of BP-induced microcrack accumulation may be significant.
This small difference in trabecular thickness, which may be a BP effect, did not reach statistical significance.
When these results are corrected for bone volume fraction, any difference between the two samples of bone not exposed to BP failed to reach significance, suggesting that osteoporotic bone is fundamentally the same biomaterial as normal bone – there is just less of it.