Superior reductions in hepatic steatosis and fibrosis with co-administration of a glucagon-like peptide-1 receptor agonist and obeticholic acid in mice.

AMLN-diet fed Lep ob /Lep ob mice showed a trend towards increased plasma ALT plasma (13%, Table 1 ) while AST levels showed a significant decrease (−31%, Table 1 ) compared to Lep ob /Lep ob mice fed LFD.

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OCA + IP118 co-administration tended to further reduce glucose levels, but this did not reach statistical significance compared to IP118 at any timepoint during the test or by assessing area under the curve ( Figure 5 E, area under the curve data not shown).

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