Suppression of Th17-polarized airway inflammation by rapamycin.

In the LNs Th17 cells were also significantly suppressed by rapamycin treatment with a strong trend towards reduction of Th1 cells (Fig. 5d,e ).

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We did observe a trend towards reduced IFNγ secretion in the LNs with both rapamycin doses, however the values failed to reach statistical significance (4 mg/kg CI: 3693–26295 pg/ml vs. 1465–16855 pg/ml; 8 mg/kg CI: 4620–37460 pg/ml vs. −14493–44747 pg/ml, Fig. 4l–m ).

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