Prospective study of autism phenomenology and the behavioural phenotype of Phelan-McDermid syndrome: comparison to fragile X syndrome, Down syndrome and idiopathic autism spectrum disorder.

The correlation between SCQ score and mood score approached significance ( r s (28) = − .37, p = .043).

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Item-level analyses extended these findings to reveal that the PMS group evidenced specific impairments in “nodding to communicate yes ”, with a higher proportion of the PMS sample scoring as impaired on this item than all three comparison groups, although this did not reach statistical significance when compared to the idiopathic ASD group who scored over the autism threshold.

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