showed a trendp = 0.0892
IL-4 showed a trend towards reduction (p = 0.0892; Supplementary Fig.
IL-4 showed a trend towards reduction (p = 0.0892; Supplementary Fig.
In addition, a reduction in TCRβ + CD4 + IFNγ + Th1 cells was observed after ABX treatment; however, this effect was heterogeneous and did not reach statistical significance (p = 0.1059, Fig. 3A and C ).
In addition, a strong and highly significant reduction in the genus Clostridium was observed, which suggests that these bacteria may promote intestinal Th17 cell differentiation and arthritis 46 .