Association of a variant in the gene encoding for ERV1/ChemR23 with reduced inflammation in visceral adipose tissue from morbidly obese individuals.

ERV1/ChemR23 −/− mice had increased levels of ALT, a surrogate serum marker of liver injury, and showed an increasing trend in insulin resistance and serum glucose levels (Fig. 5A and B ).

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Expression of IL-6 were slightly higher in livers from ERV1/ChemR23 −/− mice, although differences did not reach statistical significance (Fig. 4B ).

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Plasma insulin and GGT showed a trend towards reduced levels in patients carrying the minor C allele (Fig. 3B and C ).

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