Differences in the Thoracic Aorta by Region and Sex in a Murine Model of Marfan Syndrome.

The Marfan descending thoracic aorta from 6-mo-old mice showed a trend ( P = 0.059) toward decreased contraction in males only (Figure 2A ).

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In Marfan females, L-NAME addition induced higher Phe-induced contractions than in the wild types (Figure 4A ), though the increased area under the curve did not reach statistical significance (Figure 4B ).

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