Although we did not detect significant difference between the groups (p = 0.17), a clear trend towards increased levels was evident in the ‘late’ group.
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The scavenging chemokine receptor ACKR2 has a significant impact on acute mortality rate and early lesion development after traumatic brain injury.
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Of note however, ACKR2 -/- mice showed a tendency to maintain a prolonged elevation of CCL2 at 24 h post-CHI as compared to WT mice, though this trend did not reach statistical significance.