Association of Longitudinal Cognitive Decline With Amyloid Burden in Middle-aged and Older Adults: Evidence for a Dose-Response Relationship.

Using the more stringent 3-SD threshold, the SUVR × time interaction remained significant for MMSE (Est [SE] = −2.54 [1.27]; 95% CI, −5.05 to −0.03; P = .05 ) and marginally significant for episodic memory (Est [SE] = −1.18 [0.63]; 95% CI, −2.42 to 0.07; P = .06 ) (eTable 2 in the Supplement ).

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For the amyloid-positive group using the 2-SD threshold (n = 49), the SUVR × time interaction was again significant for episodic memory (Est [SE] = −1.33 [0.54]; P = .02), and approached significance for MMSE (Est [SE] = −1.91 [1.05]; P = .08) (eTable 4 and eFigure 3 in the Supplement ).

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Independent t tests indicated that amyloid-positive participants were older and more educated than amyloid-negative participants, and χ 2 tests showed a trend for a higher proportion of carriers of APOE ε4 among amyloid-positive participants.

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