Constitutive Cyclin O deficiency results in penetrant hydrocephalus, impaired growth and infertility.

A small percentage of Ccno +/- mice also developed early hydrocephalus (Figure 1D ) and they had an overall trend towards reduced survival, but this did not reach statistical significance (Figure 1C ).

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Ccno +/- mice showed a trend towards an intermediate size but were not statistically different than wild type animals (Figure 5B ).

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