The Arf6 activator Efa6/PSD3 confers regional specificity and modulates ethanol consumption in Drosophila and humans.

We also found a nominally significant association of rs13265422 with frequency of binge drinking in the last 30 days, a measure of alcohol abuse ( r = 0.06, t = 2.06, P = 0.040; girls: r = 0.09, t = 2.48, P = 0.013; boys: r = 0.02, t = 0.52, P = 0.60), and again there was no significant difference between boys and girls ( z = 1.33, P = 0.18).

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Because variants in the human ortholog of Efa6 showed a trend towards gender-specific phenotypes (albeit non-significant; see below), and the above experiments were performed in male flies (see also legend to Figure 1 ), we also tested Drosophila Arf6 and Ef6 mutant females.

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