An antibiotic stewardship exercise in the ICU: building a treatment algorithm for the management of ventilator-associated pneumonia based on local epidemiology and the 2016 Infectious Diseases Society of America/American Thoracic Society guidelines.

42 One retrospective study showed a trend toward increased mortality in patients with ESBL-producing Enterobacteriaceae bacteremia treated empirically with FEP as compared to carbapenems, yet this trend did not reach statistical significance. 43 However, other patient-specific characteristics, most notably severity of illness, were more si

also in 53,322 other papers

42 One retrospective study showed a trend toward increased mortality in patients with ESBL-producing Enterobacteriaceae bacteremia treated empirically with FEP as compared to carbapenems, yet this trend did not reach statistical significance. 43 However, other patient-specific characteristics, most notably severity of illness, were more significant predictors of patient outcomes. 43 In another multicenter retrospective study between 2002 and 2007, Lee et al 44 showed that FEP is a potentially effective option for treating bacteremia caused by ESBL-producing Enterobacteriaceae, but only if the MIC of the infecting organism was sufficiently low (i.e., ≤1 μg/mL).

also in 111,027 other papers

Similar to the findings by Chopra et al, 43 a nonsignificant trend toward increased mortality was observed in patients treated with FEP versus those treated with carbapenems.

also in 5,406 other papers