Transcriptional risk scores link GWAS to eQTLs and predict complications in Crohn's disease.

Nat Genet · 2017 · PMC5745037 · PMID 28805827

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approached significanceno p-value reported

Consistent with recent GWAS results indicating independent genetic contributions to susceptibility and prognosis in Crohn's disease 18 , no PRS approached significance for disease progression, which further highlights the enhanced resolution provided by TRS.

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highly significantno p-value reported

For the SMR analyses, Supplementary Figure 3a shows the strong relationship between the SMR p-value and highly significant p-values for both the GWAS and eQTL effects.

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nominally significantno p-value reported

Gene selection with SMR and coloc Detection of nominally significant associations both for eQTL and with IBD at a single SNP does not necessarily imply that the SNP is responsible for both effects.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.