517.1 ± 164.4 μg/g dry tissue), which appeared to be reduced after Cp administration (1,208 ± 241.8 μg/g dry tissue), however, did not reach statistical significance ( Appendix Fig S3 ).
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Ceruloplasmin replacement therapy ameliorates neurological symptoms in a preclinical model of aceruloplasminemia.
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The sentences
We did not investigate in detail the effect of the Cp ERT on the systemic deficiencies in CpKO mice, but we found that the significant high iron concentration detected in the liver of CpKO mice showed a trend in reduction after Cp treatment.