A polygenic risk score analysis of psychosis endophenotypes across brain functional, structural, and cognitive domains.

Importantly, there are highly significant differences in polygenic scores between the clinical groups, both in this sample and in previous studies (Bramon et al., 2014 ; Derks et al., 2012 ; Purcell et al., 2009 ; Ripke et al., 2014 ), indicating that this measure does capture genetic variants that differ between patients, unaffected relatives, and healthy controls.

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It is nevertheless interesting that for bipolar disorder, the association with block design approached significance at the most stringent threshold; this is the genome‐wide significant threshold and included only four SNPs that have been associated with bipolar disorder.

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Nevertheless, it is striking that the variance explained by the schizophrenia scores is larger for ventricular volume than for any other endophenotype we examined, with p ‐values approaching significance, and the question remains whether with larger samples one might see an association.

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