IL-33/ST2 signaling contributes to radicular pain by modulating MAPK and NF-κB activation and inflammatory mediator expression in the spinal cord in rat models of noncompressive lumber disk herniation.

J Neuroinflammation · 2018 · PMC5766999 · PMID 29329586

Europe PMC DOI

hedged sentences

0.0100

closest p · 0.2× alpha

0.0710

boldest claim

The sentences

showed a trendp < 0.01actually significant

Compared with the LV-NC group or the control group, the IL-33-siRNA-1 and IL-33-siRNA-2 groups showed a trend toward less expression of IL-33 mRNA and protein (overall p < 0.01), whereas no significant difference in IL-33 mRNA and protein expression were observed between the control group and the LV-NC group or the IL-33-siRNA-3 group.

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did not reach statistical significancep = 0.071so close (0.05 < p ≤ 0.1)

Moreover, compared with the LV-NC group, the LV-shIL-33 group (10 μl) showed decreased expression of p-JNK protein ( p < 0.05), while the LV-shIL-33 (5 μl) group showed modestly reduced expression of p-JNK protein; the difference did not reach statistical significance ( p = 0.071).

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