Granulocyte-colony stimulating factor controls neural and behavioral plasticity in response to cocaine.

Interestingly, while some analytes that were significantly regulated in only one paradigm showed a trend in the same direction in the other paradigm (e.g., KC, MIP-2), there were several that showed a relatively strong regulation in one cocaine administration paradigm, but no change at all in the other (for statistics and values, please see Supplementary Data 1 ).

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There was a strong trend toward decreased preference in these animals, but there was no statistically significant between-group difference (Fig. 7a ; two-tailed Student’s t -test: t (13) = 1.48, p = 0.16).

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