showed a trendp = 0.06
Of quantitative SC-MRI metrics, spinal cord MTR showed a trend toward being lower in RIS vs HCs ( p = 0.06), and there was already evidence of brain atrophy ( p = 0.05).
Of quantitative SC-MRI metrics, spinal cord MTR showed a trend toward being lower in RIS vs HCs ( p = 0.06), and there was already evidence of brain atrophy ( p = 0.05).
29 , 30 Accordingly, in our study, we found a clear trend toward evidence of brain atrophy in RIS vs HCs, which is in keeping with previous studies that have demonstrated atrophy in brain regions of RIS, including whole-brain, cortical GM, and the thalamus. 14 , 31 , 32 In our study, the difference in brain atrophy observed in RIS vs HCs was likely of borderline statistical significance simply because of the small sample size.