Observational study of the differential impact of time-varying depressive symptoms on all-cause and cause-specific mortality by health status in community-dwelling adults: the REGARDS study.

BMJ Open · 2018 · PMC5780736 · PMID 29306879

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Baseline depressive symptoms were significantly associated with all-cause mortality (aHR 1.18, 95% CI 1.07 to 1.29) and non-CVD death (aHR 1.21, 95% CI 1.08 to 1.36) and approached significance for CVD death (aHR 1.10, 95% CI 0.94 to 1.29) and cancer death (aHR 1.12, 95% CI 0.93 to 1.36), even in the exploratory models (model 3).

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approaching significanceno p-value reported

Time-varying depressive symptoms significantly predicted non-CVD disease death (aHR 1.29, 95% CI 1.16 to 1.44) and all-cause mortality (adjusted HR (aHR) 1.24, 95% CI 1.14 to 1.36), while approaching significance for cancer death (aHR 1.15, 95% CI 0.96 to 1.38) and CVD death (aHR 1.13, 05% CI 0.98 to 1.32), even after adjusting for demographic, clinical, behavioural and physiological factors and time-varying non-fatal CVD events ( table 2 , online supplementary efigure 3 ).

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