Decreased Sirtuin Deacetylase Activity in LRRK2 G2019S iPSC-Derived Dopaminergic Neurons.

Stem Cell Reports · 2017 · PMC5785678 · PMID 29129681

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showed a trendno p-value reported

Acetylated p53 is a known direct target of SIRT1 and showed a trend toward increased expression in LRRK2 G2019S iPSC-derived dopaminergic neurons compared with controls ( Figures 4 E and 4F), indicating reduced SIRT1 activity.

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a strong trendno p-value reported

We also found a strong trend toward increased acetylated p53 (∼2- to 3-fold) in LRRK2 G0291S iPSC-derived dopaminergic neurons compared with controls, a direct target of SIRT1, which may contribute to the vulnerability of dopaminergic neurons to oxidative stress in PD.

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