Significant transcriptional changes in 15q duplication but not Angelman syndrome deletion stem cell-derived neurons.

Both DPSC and DPSC-derived neurons showed a significant trend with respect to copy number ( p value ≤ 1 × 10 −4 ) indicating that as copy number increased, so did gene expression for genes in the 15q region.

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Although they did not reach statistical significance, there were other downregulated genes involved in this process as well in the nominal p value range of ≤ 1% (notably GO: “Chromatin Assembly and Disassembly” and “Establishment or Maintenance of Chromatin Architecture” nominal p values ≤ 0.05).

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