Down selecting adjuvanted vaccine formulations: a comparative method for harmonized evaluation.

Day 70 IgG1 titres were highest in the QS21-Liposomes group and this was significantly higher as compared to the AlOH group ( p = 0.0052, MW test), but failed to reach significance for the comparison with the SWE group after correction for multiple tests ( p = 0.0175, MW test) (Fig. 4 ).

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The number of IL-5 spots tended to be higher in the QS21-Liposomes group as compared to the SWE-group, but this did not reach statistical significance ( p = 0.019, MW test).

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For AMA1 the median number of IL-5 spots was 69, 150 and 92 for AlOH, SWE and QS21-Liposomes respectively, this, however, failed to reach statistical significance ( p = 0.064, KW test) (Fig. 2 ).

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For AMA1 the median number of IFN-γ spots showed an increasing trend over the adjuvants/groups from 19 in the AlOH, to 60 for the SWE and to 150 for the QS21-Liposomes groups (Fig. 1 ), but none of the comparisons reached statistical significance ( p = 0.081, KW test).

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