Low apolipoprotein A-I levels in Friedreich's ataxia and in frataxin-deficient cells: Implications for therapy.

However, the differences did not reach statistical significance.

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Modulation of HMG-CoA and MVA metabolite formation by frataxin knockdown Baseline levels of HMG-CoA (determined by UPLC-HRMS) in sFXN#10 group (117.4 ± 17.2%, Fig 7B ) and sFAN#11 knockdown group (134.3 ± 31.1%, Fig 7B ) showed a trend to higher levels than the si-NC group (100.0 ± 17.3%, Fig 7B ) and in regular HepG2 group (100.4 ± 54.3%, Fig 7B ).

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