Interleukin 8 activity influences the efficacy of adenoviral oncolytic immunotherapy in cancer patients.

However, partly due to the small sample size, the difference did not reach statistical significance despite pooling of the increase and no-change groups (Fisher’s exact test p=0.066).

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Change in IL-8 expression was not correlated with overall survival, but as seen for IL-8 analysis in blood, we observed an interesting trend for longer survival in patients with low pre-treatment IL-8 expression in tumors, although the difference did not reach statistical significance (p=0.058) in this small patient cohort.

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In an extension cohort of patients, low baseline IL-8 RNA expression in tumor biopsy or effusion samples showed a trend for longer overall survival.

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