Increased fecal calprotectin levels in Crohn's disease correlate with elevated serum Th1- and Th17-associated cytokines.

PLoS One · 2018 · PMC5821357 · PMID 29466406

Europe PMC DOI

hedged sentences

0.0100

closest p · 0.2× alpha

0.0580

boldest claim

The sentences

highly significantP < 0.01actually significant

Results A highly significant positive correlation was observed between the pro-inflammatory serum cytokines IFN-γ and CRP and fecal calprotectin levels ( P < 0.01).

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borderline non-significantP = 0.058so close (0.05 < p ≤ 0.1)

Furthermore, an interesting additional finding is the borderline non-significant enhancement of serum IL-17A levels ( P = 0.058) in CD patients with increased fecal calprotectin levels.

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did not reach statistical significanceno p-value reported

Our data not only provide correlations between fecal calprotectin levels and inflammatory markers in the systemic circulation, but also confirm that Th1 responses are important in CD patients with active disease since IFN-γ levels were significantly elevated, as well as serum TNF-α levels, although the latter did not reach statistical significance.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.