AmpliSeq Screening of Genes Encoding the C-Type Lectin Receptors and Their Signaling Components Reveals a Common Variant in <i>MASP1</i> Associated with Pulmonary Tuberculosis in an Indian Population.

Front Immunol · 2018 · PMC5826192 · PMID 29515573

Europe PMC DOI

hedged sentences

0.0028

closest p · 0.1× alpha

0.0340

boldest claim

The sentences

highly significantp = 0.0028actually significant

Joint analysis of phases I and II confirmed our findings, with a highly significant association of rs3774275 with pulmonary tuberculosis (joint analysis OR = 0.61 95%CI = 0.43–086, p = 0.0028; see Table 2 ).

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nominally significantp = 0.0340actually significant

Among the remaining 13 common variant candidates, only one SNP (rs3774275; MASP1 ) was nominally significant in phase II ( p = 0.0340, Table 2 ), showing the same direction of effects as in phase I.

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failed to reach statistical significanceno p-value reported

In our study, we also observed higher MASP1 levels in the GG-genotype of the control population, but failed to reach statistical significance, probably due to the small sample size for this minor genotype.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.