Somatic Mitochondrial DNA Mutations in Diffuse Large B-Cell Lymphoma.

Heteroplasmic constitutional alleles showed a significant trend towards reduction or loss of the minor allele – represented as decreases in HF – in the corresponding tumour (p = 0.00047, t = 3.815).

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Heteroplasmic constitutional variants showed a trend towards loss of heteroplasmy in the corresponding tumour regardless of whether the reference or variant allele was being lost, suggesting that these variants are selectively neutral.

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